We focus on understanding how epigenetic regulation drives cancer progression. We study how chromatin dynamics and gene activation programs contribute to cellular plasticity, invasion, and metastasis.
We examine how DNA methylation, chromatin accessibility, and transcriptional control regulate gene expression programs in cancer.
We investigate CTAs, including XAGE and MAGE family proteins, which are normally restricted in expression but become aberrantly activated in tumors.
We study molecular mechanisms that enable cancer cells to acquire invasive and migratory phenotypes, including signaling pathways and regulatory networks.
Molecular and cellular biology
Functional assays (invasion, viability, phenotypic analysis)
Gene expression and protein interaction studies